The Western Bulldogs ran over the top of injury-ravaged Collingwood to claim a 21-point victory in the AFL match at the MCG on Sunday.
When young forward Darcy Moore went off early in the last quarter with a game-ending shoulder injury the Magpies were left with no fit players on the interchange bench.
Alan Toovey was the first Magpie to depart the match after being heavily concussed in the second term.
The injury curse got much worse for the Magpies in the third quarter, with midfielder Taylor Adams suffering a left hamstring injury, while forward Alex Fasolo had his match ended by a left shoulder injury.
ICYMI: Magpie Taylor Adams suffered a hamstring injury against the Bulldogs today. https://t.co/Y2pDyD7sSp— AFL (@AFL) May 29, 2016
Moore's shoulder injury was the final straw with Collingwood unable to make any interchanges for most of the final term.
The Magpies still held a three-point lead at the final change but they were eventually swamped by the Bulldogs, who kicked five goals to one in the fourth quarter to win 11.8 (74) to 7.11 (53).
The Bulldogs kicked the final four goals of the match.
Midfielders Luke Dahlhaus, Lachie Hunter and Tom Liberatore and stand-in skipper Easton Wood were among the best players for the Bulldogs, who improved their win-loss record to 7-3.
The Magpies got great returns from rebounding backman Jeremy Howe and onball stars Scott Pendlebury and Steele Sidebottom.
Collingwood will need to call on fresh troops before returning to the MCG next Sunday to take on Port Adelaide.
The Bulldogs' next challenge is against West Coast at Etihad Stadium.